2. Gene
  3. TLK1 - tousled like kinase 1 Gene

TLK1 - tousled like kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：凌乱样激酶 1

种属: Homo sapiens

同用名: PKU-beta

基因 ID: 9874 | 基因类型: protein coding

关于 TLK1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:170,990,823-171,231,293 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.5), thyroid (RPKM 10.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种丝氨酸/苏氨酸激酶，可能参与染色质组装的调节。编码的蛋白质只有在磷酸化时才有活性，这种磷酸化依赖于细胞周期，该蛋白质的最大活性出现在 S 期。这种蛋白质的催化活性会因 DNA 损伤和 DNA 复制受阻而减弱。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

TLK1 基因产物(3)

mRNA Protein Name
NM_001136554.2 NP_001130026.1 serine/threonine-protein kinase tousled-like 1 isoform 2
NM_001136555.2 NP_001130027.1 serine/threonine-protein kinase tousled-like 1 isoform 3
NM_012290.5 NP_036422.3 serine/threonine-protein kinase tousled-like 1 isoform 1

TLK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (458 - 734)

  • 0
  • 200
  • 400
  • 600
  • 766 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase tousled-like 1

SNARE protein kinase SNAK

重组 TLK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76676 TLK1 Protein, Human (sf9, His-GST) Q9UKI8 (M1-Y766) ≥95%

关联疾病

疾病名称 别名
Pica Disease

Pica
Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

SPGF5

Macrocephalic Sperm Head Syndrome

Male Infertility Due To Macrozoospermia

Infertility Associated With Multitailed Spermatozoa And Excessive Dna

Macrozoospermia

Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

Large-Headed Multiflagellar Polyploid Spermatozoa

Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14570 TLK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TLK1 VGNC VGNC:66211
Mus musculus TLK1 MGD MGI:2441683
Canis familiaris TLK1 VGNC VGNC:47398
Macaca mulatta TLK1 VGNC VGNC:78367
Rattus norvegicus TLK1 RGD RGD:1310370
Bos taurus TLK1 VGNC VGNC:35893
Others TLK1 NCBI
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