2. Peptides
  3. Gly-Pro-Glu

Gly-Pro-Glu 是一种神经活性肽，能有效激活乙酰胆碱的释放。Gly-Pro-Glu 是 insulin-like growth factor-I 的 N 端三肽。Gly-Pro-Glu 抑制谷氨酸与 N-methyl-D-aspartate (NMDA) 受体结合，IC50 值为 14.7 μM。Gly-Pro-Glu 可用于神经保护的研究。

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Custom Peptide Synthesis

Gly-Pro-Glu Chemical Structure

Gly-Pro-Glu Chemical Structure

CAS No. : 32302-76-4

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规格 价格 是否有货 数量
5 mg ￥500
In-stock
10 mg ￥800
In-stock
25 mg ￥1600
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50 mg ￥2600
In-stock
100 mg ￥4100
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Gly-Pro-Glu 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection [1][2].

IC50 & Target

IC50: 14.7 μM (glutamate binds to NMDA receptor)[1]
体外研究
(In Vitro)

Gly-Pro-Glu (0-100 μM) potentiates the potassium evoked release of both acetylcholine and dopamine, increases K+ evoked acetylcholine release even at concentrations of 0.1 nM and significantly enhances evoked dopamine release[1].
Gly-Pro-Glu (1-1000 μM) shows an inhibition of L-[3H]glutamate binding with an IC50 value of 14.7 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gly-Pro-Glu 相关抗体:
体内研究
(In Vivo)

Gly-Pro-Glu (300 mg; i.p. once per day; on day 0, 6 and 12) shows an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult.[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovariectomized rats with Abeta25-35 injection[2]
Dosage: 300 mg
Administration: Intraperitoneal injection; 300 mg per day; on day 0, 6 and 12
Result: Recovered Abeta25-35-induced the reduction of somatostatin (SRIF) content and SRIF receptor density, and reduced the inhibitory effect of SRIF on adenylyl cyclase activity.
分子量

301.30

Formula

C12H19N3O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 66.67 mg/mL (221.27 mM; ultrasonic and adjust pH to 2 with 1M HCl; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3190 mL 16.5948 mL 33.1895 mL
5 mM 0.6638 mL 3.3190 mL 6.6379 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3190 mL 16.5948 mL 33.1895 mL 82.9738 mL
5 mM 0.6638 mL 3.3190 mL 6.6379 mL 16.5948 mL
10 mM 0.3319 mL 1.6595 mL 3.3190 mL 8.2974 mL
15 mM 0.2213 mL 1.1063 mL 2.2126 mL 5.5316 mL
20 mM 0.1659 mL 0.8297 mL 1.6595 mL 4.1487 mL
25 mM 0.1328 mL 0.6638 mL 1.3276 mL 3.3190 mL
30 mM 0.1106 mL 0.5532 mL 1.1063 mL 2.7658 mL
40 mM 0.0830 mL 0.4149 mL 0.8297 mL 2.0743 mL
50 mM 0.0664 mL 0.3319 mL 0.6638 mL 1.6595 mL
60 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3829 mL
80 mM 0.0415 mL 0.2074 mL 0.4149 mL 1.0372 mL
100 mM 0.0332 mL 0.1659 mL 0.3319 mL 0.8297 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gly-Pro-Glu32302-76-4Othersneuroactive peptideNMDAinsulintripeptideacetylcholinedopamineInhibitorinhibitorinhibit

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产品名称：
Gly-Pro-Glu
目录号：
HY-117483
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