2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GS87

GS87 是一种高度特异性的 GSK3 抑制剂，对 GSK3α 和 GSK3β 的IC50 分别为 415nM 和 521nM。GS87 通过有效地激活 GSK3 依赖性信号成分(包括 MAPK 信号)诱导急性髓性白血病 (AML) 细胞系的分化。GS87 比 Lithium 和 SB415285 (SB) 更有效地调节参与细胞增殖和分化的关键 GSK3 靶蛋白。GS87 具有作为非早幼粒细胞 AML 分化剂研究的潜力。

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GS87 Chemical Structure

GS87 Chemical Structure

CAS No. : 919936-70-2

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规格 价格 是否有货 数量
5 mg ￥3383
3 - 4 周
10 mg ￥5416
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

GS87 相关抗体

Top Publications Citing Use of Products

查看 GSK-3 亚型特异性产品:

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GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].

IC50 & Target[1]

GSK3α

415 nM (IC50)

GSK3β

521 nM (IC50)

分子量

337.36

Formula

C16H11N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GS87 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS87919936-70-2GS 87GS-87GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3GSK3GSK3αGSK3βdifferentiationAMLMAPKInhibitorinhibitorinhibit

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目录号：
HY-134557
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