2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 6

GSK-3β inhibitor 6 是一种有效的 GSK-3β 抑制剂，IC50 值为 24.4 μM，并显示出较高的肝细胞葡萄糖摄取率 (38%)。GSK-3β inhibitor 6 可用于糖尿病、炎症、癌症、阿尔茨海默病和双相情感障碍等多种疾病的研究。

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GSK-3β inhibitor 6 Chemical Structure

GSK-3β inhibitor 6 Chemical Structure

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GSK-3β inhibitor 6 相关抗体

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查看 GSK-3 亚型特异性产品:

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GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK-3β inhibitor 6 is a potent GSK-3β inhibitor with an IC50 value of 24.4 μM. GSK-3β inhibitor 6 shows high hepatocyte glucose uptake (38%). GSK-3β inhibitor 6 can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder[1].

IC50 & Target[1]

GSK-3β

24.4 μM (IC50)

体外研究
(In Vitro)

GSK-3β inhibitor 6 (Compound B30, 0-30 μΜ, 30 min) shows good GSK-3β kinase inhibitory activity (IC50: 24.4 μM)[1].
GSK-3β inhibitor 6 (5 μM, 3 h) shows high hepatocyte glucose uptake (38%) with no significant toxicity against HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSK-3β inhibitor 6 相关抗体:
体内研究
(In Vivo)

GSK-3β inhibitor 6 (Compound 5k, oral administration, 20 mg/kg) shows favorable drug-like properties (t1/2: 1.41 h, Cmax: 288 ng/mL)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (pharmacokinetic assay)[2]
Dosage: 2 mg/kg, 20 mg/kg
Administration: Intravenous injection (2 mg/kg), oral administration (20 mg/kg)
Result: Pharmacokinetic profile of GSK-3β inhibitor 6 (Compound 5k).
Compound Route Dose (mg/kg) t1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (hr•ng/mL) AUC0-∞ (hr•ng/mL) CL (mL/hr/kg) F (%)
GSK-3β inhibitor 6 Oral administration 20 1.41 1.33 288 1030 1073 18719 11.4
GSK-3β inhibitor 6 Intravenous injection 2 2.13 0.08 449 872.89 940.48 2190.83
F: oral bioavailability.
分子量

393.28

Formula

C20H17BrN4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK-3β inhibitor 6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 6GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3DiabetesinflammationcancerAlzheimer's diseasebipolar disorderglucoseHepG2Inhibitorinhibitorinhibit

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目录号：
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