2. Epigenetics
  3. Histone Methyltransferase
  4. GSK591 hydrochloride

GSK591 hydrochloride  (Synonyms: EPZ015866 hydrochloride; GSK3203591 hydrochloride)

目录号: HY-100235A
产品使用指南

摩尔计算器

GSK591 (EPZ015866) hydrochloride 是一种有效的，选择性的 protein methyltransferase 5 (PRMT5) 抑制剂，其 IC50 值为 4 nM。

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GSK591 hydrochloride Chemical Structure

GSK591 hydrochloride Chemical Structure

CAS No. : 2320953-89-5

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GSK591 hydrochloride 的其他形式现货产品:

Other Forms of GSK591 hydrochloride:

GSK591 hydrochloride 相关抗体

Top Publications Citing Use of Products

    GSK591 hydrochloride purchased from MCE. Usage Cited in: Exp Cell Res. 2022 Nov 16;422(1):113413.  [Abstract]

    GSK591 (PRMT5i; 200-1000 nM) in combination with EPZ020411 (PRMT6i; 200-1000 nM) exhibits a synergistic anti-proliferative effect on HCT116 and SW620 cells.

    查看 Histone Methyltransferase 亚型特异性产品:

    查看所有亚型
    EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

    • 生物活性

    • 纯度 & 产品资料

    生物活性

    GSK591 (EPZ015866) hydrochloride is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 4 nM[1].

    IC50 & Target

    IC50: 4 nM (PRMT5)[1]
    分子量

    453.41

    Formula

    C22H30Cl2N4O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料

    GSK591 hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GSK5912320953-89-5EPZ015866GSK3203591GSK 591GSK-591EPZ 015866EPZ-015866GSK 3203591GSK-3203591Histone MethyltransferaseInhibitorinhibitorinhibit

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    目录号：
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