2. Neuronal Signaling
  3. Cholinesterase (ChE) Beta-secretase Amyloid-β
  4. hAChE/hBACE-1-IN-2

hAChE/hBACE-1-IN-2 是一种有效的，具有口服活性的，可透过血脑屏障的 hAChE/hBChE/hBACE-1 三重抑制剂，IC50 值分别为 0.113 μM, 1.48 μM 和 0.38 μM。hAChE/hBACE-1-IN-2 具有抗氧化活性。hAChE/hBACE-1-IN-2 也抑制 Aβ11-42 聚集。hAChE/hBACE-1-IN-2 可用于研究阿尔茨海默症。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

hAChE/hBACE-1-IN-2 Chemical Structure

hAChE/hBACE-1-IN-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

hAChE/hBACE-1-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Beta-secretase 亚型特异性产品:

查看所有亚型
BACE1 BACE2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hAChE/hBACE-1-IN-2 is a potent, orally active, blood-brain barrier transboundary triple inhibitor of hAChE, hBChE, and HACE-1 with IC50s of 0.113 μM, 1.48 μM and 0.38 μM, respectively. hAChE/hBACE-1-IN-2 has antioxidant activity. hAChE/hBACE-1-IN-2 also inhibits Aβ11-42 aggregation. hAChE/hBACE-1-IN-2 can be used to study Alzheimer's disease[1].

IC50 & Target

hAChE

0.113 μM (IC50)

hBACE-1

0.38 μM (IC50)

hBCHE

1.48 μM (IC50)

体外研究
(In Vitro)

hAChE/hBACE-1-IN-2 (compound 5f) (10-80 μM, 72 h) 在 SH-SY5Y 神经母细胞瘤细胞系中的安全性被认为与 Donepezil (HY-14566) 相似[1]。
hAChE/hBACE-1-IN-2 (compound 5f) (20 μM; 48 h, 72 h) 在 SH-SY5Y 神经母细胞瘤细胞系中具有抗 Aβ1-42 聚集电位的潜能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hAChE/hBACE-1-IN-2 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y cell lines (The SH-SY5Y cells were sequentially treated with RA and BDNF for 6 days)
Concentration: 10, 20, 40, and 80 μM
Incubation Time: 48-72 h
Result: Indicated a similar reduction in the differentiated neuroblastoma cell population at a maximum 80 μM concentration.

Cell Viability Assay[1]

Cell Line: Aβ1-42 treated SH-SY5Y cells (incubated with Aβ1-42 (10μM) for 24 h)
Concentration: 20 μM
Incubation Time: 48-72 h
Result: The cells incubated the cell viability to 65% and 75% after 48 h and 72 h.
体内研究
(In Vivo)

hAChE/hBACE-1-IN-2 (2.5-10 mg/kg，口服， 14 天) 在 Scopolamine (HY-N0296) 诱导的认知缺陷小鼠模型中改善小鼠学习和记忆能力，减少 RTL 和张开双臂的时间[1]。
hAChE/hBACE-1-IN-2 ( 500 mg/kg，口服， 14 天) 在瑞士白化小鼠中耐受良好，没有明显毒性，包括大脑，肝脏，肾脏和心脏均没有异常[1]。
hAChE/hBACE-1-IN-2 (10 mg/kg，口服， 14 天) 在 Scopolamine (HY-N0296) 诱导的小鼠模型中能够透过血脑屏障，降低海马和皮层脑匀浆中 AchE 水平或底物水解，延缓氧化应激和降低促炎细胞因子水平的潜力[1]。
hAChE/hBACE-1-IN-2 (10 mg/kg，口服， 14天) 在 Aβ 诱导的模型中抑制 BACE-1、 Aβ、 APP/Aβ 和 tau 蛋白水平，保护不同脑区的脑组织[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice[1]
Dosage: 500 mg/kg
Administration: Oral administration (p.o.), 14 days
Result: Showed no signs or symptoms of toxicity over the 14 days
Animal Model: Scopolamine-induced cognitive deficit mouse model[1]
Dosage: 2.5 mg, 5 mg, and 10 mg/kg
Administration: Oral administration (p.o.), 14 days
Result: Elevated plus maze test showed significant reductions in transfer latency and time spent in open arms, similar to the effects observed with Scopolamine (HY-N0296)-induced dementia reversal.
分子量

408.52

Formula

C22H24N4O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hAChE/hBACE-1-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hAChE/hBACE-1-IN-2Cholinesterase (ChE)Beta-secretaseAmyloid-βBACEβ-Secretase β-amyloid peptideAβAbetaSH-SY5Yblood-brain barrierMTDLscopolamine-induced amnesia modelAlzheimer’s diseaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
hAChE/hBACE-1-IN-2
目录号：
HY-149288
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z