2. Cell Cycle/DNA Damage Epigenetics Neuronal Signaling
  3. HDAC Amyloid-β Cholinesterase (ChE)
  4. HDAC6-IN-6

HDAC6-IN-6 (化合物 6a) 是一种有效的透过血脑屏障的 HDAC6 抑制剂，其 IC50 为0.025 μM。HDAC6-IN-6 对 Aβ1-42 自聚集和 AChE 表现出较强的抑制活性，IC50 值分别为 3.0 和 0.72 μM。HDAC6-IN-6 可促进神经突起生长，且无明显神经毒性。

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HDAC6-IN-6 Chemical Structure

HDAC6-IN-6 Chemical Structure

CAS No. : 2413603-10-6

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HDAC6-IN-6 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].

IC50 & Target

HDAC6

0.025 ± 0. μM (IC50)

HDAC1

0.34 ± 0.0 μM (IC50)

HDAC

0.55 ± 0.0 μM (IC50)

HDAC9

0.57 ± 0.0 μM (IC50)

HDAC7

0.65 ± 0.0 μM (IC50)

HDAC5

0.85 ± 0.0 μM (IC50)

HDAC3

1.22 ± 0.0 μM (IC50)

HDAC2

1.57 ± 0.0 μM (IC50)

HDAC4

2.24 ± 0.0 μM (IC50)

体外研究
(In Vitro)

HDAC6-IN-6 (compound 6a) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 7.96 and 8 μM, respectively[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-6 相关抗体:
分子量

329.35

Formula

C20H15N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-62413603-10-6HDACAmyloid-βCholinesterase (ChE)Histone deacetylasesβ-amyloid peptideAβAbetaNeuro-2a cellsneuroblastomaHistone deacetylaseAcetylcholine esteraseAcridineMultitargetAlzheimer’s disease (AD)Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-146679
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