ICI-63197 

ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with K_i values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects^[1][2].

在先前与 [³H]-去甲肾上腺素孵育的兔离体肺动脉中，ICI-63197 (30 μM) 显着增强刺激引起的放射性流出^[3]。
在小鼠心房中刺激频率为 2 Hz 时，ICI-63197 (30 μM) 对刺激引起的流出没有影响^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

腹腔给药后 30 分钟和 90 分钟，ICI 63197 (0.48-29.9 µmol/kg) 剂量依赖性地拮抗利血平引起的小鼠体温过低^[2]。
ICI-63197 增强直接给予大鼠伏核的多巴胺或麦角多巴胺激动剂麦角乙脲的运动刺激作用。ICI-63197 具有增强中枢去甲肾上腺素能传输的特性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

207.23

C₉H₁₃N₅O

27277-00-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. M Hoey, et al. Identification and selective inhibition of four distinct soluble forms of cyclic nucleotide phosphodiesterase activity from kidney. Biochem Pharmacol. 1990 Jul 15;40(2):193-202.  [Content Brief]

  [2]. H Wachtel. Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology. 1983 Mar;22(3):267-72.  [Content Brief]

  [3]. H Johnston, et al. Prejunctional beta-adrenoceptors in rabbit pulmonary artery and mouse atria: effect of alpha-adrenoceptor blockade and phosphodiesterase inhibition. Br J Pharmacol. 1986 Mar;87(3):553-62.  [Content Brief]