2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Isopropyl unoprostone

Isopropyl unoprostone  (Synonyms: 异丙基乌诺前列酮; Unoprostone isopropyl ester; UF-021)

目录号: HY-109545
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摩尔计算器

Isopropyl unoprostone (Unoprostone isopropyl ester)，一种前列腺素代谢物的类似物，是大电导钙激活钾通道 (BK channels) 激活剂。Isopropyl unoprostone 具有抗青光眼的作用，通过增加房水流出降低眼压。Isopropyl unoprostone 可提高视网膜敏感度，保护视网膜中央敏感度。

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Isopropyl unoprostone Chemical Structure

Isopropyl unoprostone Chemical Structure

CAS No. : 120373-24-2

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规格 价格 是否有货
1 mg ￥1278
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Isopropyl unoprostone 相关抗体

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  • 生物活性

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生物活性

Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity[1][2].

IC50 & Target

BK channels[1]
体外研究
(In Vitro)

Isopropyl unoprostone (0.01-1 μM; 24 h) protects against H2O2-induced 661W cell death[2].
Isopropyl unoprostone (0.1-3 μM; 24 h) reduced the morphological change of 661W cells and protects against light-induced cell death[2].
Isopropyl unoprostone (0.001-1 μM; 48 h) suppresses light-induced phagocytotic dysfunction in ARPE-19 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isopropyl unoprostone 相关抗体:

Apoptosis Analysis[2]

Cell Line: 661W (treated with Isopropyl unoprostone for 1 h, then added H2O2)
Concentration: 0.01, 0.1 and 1 μM
Incubation Time: 24 h
Result: Protected against H2O2-induced cell death in a concentration-dependent manner.

Apoptosis Analysis[2]

Cell Line: 661W (treated with Isopropyl unoprostone for 1 h, then exposed to 2,500 lux of white fluorescent light)
Concentration: 0.1, 1 and 3 μM
Incubation Time: 24 h
Result: Protected against light-induced cell death in a concentration-dependent manner, and the effect was significant at the 1 and 3 μM concentrations; reduced the morphological change (the transition to a rounder shape) which is potentially indicative of a pre-apoptotic stage.
分子量

424.61

Formula

C25H44O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Isopropyl unoprostone 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Isopropyl unoprostone120373-24-2Unoprostone isopropyl ester UF-021UF021UF 021UF-021Potassium ChannelKcsAprostaglandin metaboliteantiglaucomaintraocular pressureretinal661WARPE-19Inhibitorinhibitorinhibit

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