2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. JNJ-26070109

JNJ-26070109 是一种高亲和力、竞争性、口服有效的选择性胆囊收缩素 2 (CCK2) 受体拮抗剂，pKi 分别为 8.49、7.99 ，和 7.70 分别用于人类、大鼠和狗 CCK2 受体。JNJ-26070109具有良好的药代动力学特性。CCK2 受体在调节胃酸分泌和胃肠黏膜生长方面的双重功能使其成为研究胃食管反流病的有吸引力的新靶点。

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JNJ-26070109 Chemical Structure

JNJ-26070109 Chemical Structure

CAS No. : 844645-08-5

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JNJ-26070109 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selective cholecystokinin 2 (CCK2) receptor antagonist with good pharmacokinetic properties, with pKis of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the research of gastroesophageal reflux disease[1].

IC50 & Target

CCKBR

 

分子量

547.37

Formula

C23H17BrF2N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-26070109 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-26070109844645-08-5JNJ26070109JNJ 26070109Cholecystokinin ReceptorCCK Receptororally bioactivecholecystokininCCK2gastroesophageal reflux diseaseInhibitorinhibitorinhibit

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