2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. JNJ-42314415

JNJ-42314415 是一种具有中枢神经活性的磷酸二酯酶(PDE10A) 的抑制剂，其对人重组PDE10A 和rPDE10A 的Ki 值分别为 35 nM和64 nM。

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JNJ-42314415 Chemical Structure

JNJ-42314415 Chemical Structure

CAS No. : 1334165-90-0

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JNJ-42314415 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 35 nM and 64 nM for human recombinant PDE10A and rPDE10A, respectively[1].

IC50 & Target[1]

human PDE 10A

35 nM (Ki)

体内研究
(In Vivo)

JNJ-42314415 (24.7 mg/kg) 高剂量下会引起体温过低[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

353.42

Formula

C19H23N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-42314415 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-423144151334165-90-0JNJ42314415JNJ 42314415Phosphodiesterase (PDE)phosphodiesterase 10APDE10Ahypothermiaantipsychotic drugInhibitorinhibitorinhibit

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产品名称：
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目录号：
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