2. Peptides
  3. JV-1-36

JV-1-36 是一种生长激素释放激素 (GHRH) 拮抗剂。JV-1-36 具有抑制 A549 肺癌细胞活性氧生成的作用。JV-1-36 可用于 GHRH 拮抗剂体外作用的研究。

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Custom Peptide Synthesis

JV-1-36 Chemical Structure

JV-1-36 Chemical Structure

CAS No. : 221377-79-3

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JV-1-36 的其他形式现货产品:

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JV-1-36 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JV-1-36 is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro [1].

IC50 & Target

IC50: growth hormone-releasing hormone (GHRH)[1].
体外研究
(In Vitro)

JV-1-36 (0.01-15 μM; 8 h) 在 A549 细胞中，较高浓度 (5-15 μΜ) 下降低细胞活力。(2-15 μM; 8 h) 在 Hela 细胞中降低细胞活力[1]。
JV-1-36 (1 μM; 8 h) 在 A549 肺癌细胞显著降低 H2O2 (0.1 mM; 8 h) 诱导的 ROS 的产生，具有抗氧化的作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JV-1-36 相关抗体:
分子量

3785.88

Formula

C172H284ClN53O41
CAS 号
Sequence

{N-(2-phenylacetyl)}-Tyr-{d-Arg}-Asp-Ala-Ile-{4-Cl-Phe}-Thr-Asn-{Har}-{Tyr(Me)}-Arg-Lys-Val-Leu-{Abu}-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-{Nle}-{d-Arg}-{Har}-NH2
Sequence Shortening

{N-(2-phenylacetyl)}-Y-{d-Arg}-DAI-{4-Cl-Phe}-TN-{Har}-{Tyr(Me)}-RKVL-{Abu}-QLSARKLLQDI-{Nle}-{d-Arg}-{Har}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JV-1-36221377-79-3Othersinflammationlung injuryendotheliumoxidative stressA549HelaInhibitorinhibitorinhibit

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目录号：
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