Kartogenin sodium  (Synonyms: KGN sodium)

Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research^[1][2][3][4].

Kartogenin sodium（100 nM；72 h）诱导原代 hMSC 中软骨细胞结节的形成^[1]。
Kartogenin sodium（10 nM-10 μM；72 h）可增加 hMSC 中软骨细胞特异性基因的表达^[1]。
Kartogenin sodium（0.12-10 μM；48 h）可抑制原代牛关节软骨细胞中细胞因子诱导的一氧化氮 (NO) 和糖胺聚糖 (GAG) 释放^[1]。
Kartogenin sodium（50-5000 nM；2 wk）以浓度依赖性方式诱导 BMSC 的软骨分化^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kartogenin sodium（10 μM，溶于 4μL 盐水中；在第 7 天和第 21 天处理）可促进胶原酶 VII 诱导的小鼠 OA 模型中的软骨修复^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

339.32

C₂₀H₁₄NNaO₃

1401168-39-5

固体

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Johnson K, et, al. A stem cell-based approach to cartilage repair. Science. 2012 May 11;336(6082):717-21.  [Content Brief]

  [2]. Liu F, et, al. A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Stem Cell Res Ther. 2019 Jul 8;10(1):201.  [Content Brief]

  [3]. Cai J, Zhang L, Chen J, et al. Kartogenin and its application in regenerative medicine[J]. Current medical science, 2019, 39(1): 16-20.

  [4]. Zhang J, Wang J H C. Kartogenin induces cartilage-like tissue formation in tendon–bone junction[J]. Bone research, 2014, 2(1): 1-10.