2. 天然产物
  3. 疾病研究领域 植物 糖类 微生物
  4. 癌症 其他科 多糖
  5. Laminaran

Laminaran  (Synonyms: 昆布多糖)

目录号: HY-119109 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Laminaran 是一种 β-1-3-葡聚糖，源于 Eisenia Bicyclis，Dectin-1 的典型配体，具有免疫调节，辐射防护作用以及抗癌活性。 Laminaran 由具有 β (1→6) 分支的 β (1→3)-葡聚糖组成，可以被葡糖酶诸如 (EC 3.2.1.6) 之类的酶催化，该酶会破坏 β (1→3) 键。 Laminaran 是一种有前途的免疫刺激分子，用于癌症免疫的研究。

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Laminaran Chemical Structure

Laminaran Chemical Structure

CAS No. : 9008-22-4

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规格 价格 是否有货 数量
100 mg ￥500
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500 mg   询价  

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Customer Review

Laminaran 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities[1]. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds[2]. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy[3].

体外研究
(In Vitro)

Laminaran (100-800 µg/mL; 24 hours) is not cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28, the percentage of inhibition of living cells number is less than 15 % at concentrations range up to 800 µg/mL after 24 h of treatment[1].
Laminaran (200 µg/mL; 24-72 hours)does not cause any growth inhibition of SK-MEL-28 cells after 24 and 48 h of treatment, but decreases cells proliferation by 36 % after 72 h of treatment[1].
Laminaran (25-50 µg/mL; 24 hours) at low concentration does not influence the phosphorylation of c-Raf (Ser259), ERK1/2 (Tyr202/Tyr204), and MEK1/2 (Ser 221) kinases as well as total expression level of investigated proteins. But decreases p-MEK, p-ERK1/2 at 50 µg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Laminaran 相关抗体:

Cell Viability Assay[1]

Cell Line: JB6 Cl41 and SK-MEL-28 cells
Concentration: 100, 200, 400, and 800 µg/mL
Incubation Time: 24 hours
Result: Showed no cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28.

Cell Proliferation Assay[1]

Cell Line: SK-MEL-28 cells
Concentration: 200 µg/mL
Incubation Time: 24 hours
Result: Decreased cell proliferation at 72 hours.

Western Blot Analysis[1]

Cell Line: SK-MEL-28 cells
Concentration: 25 µg/mL; 50 µg/mL
Incubation Time: 24 hours
Result: Inhibited phosphorylation of c-Raf, MEK1/2, and ERK1/2 kinases.
体内研究
(In Vivo)

Laminaran (intravenous injection; 12.5, 25, and 50 mg/kg; 21 days) and OVA (50 μg) combination significanly decreases the tumor masses when it compares with the PBS-, OVA-, and laminarin-treated mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice injected s.c. with B16-OVA cells[3]
Dosage: 12.5, 25, and 50 mg/kg; 21 days
Administration: Intravenous injection
Result: Prevented B16-OVA tumor growth by inducing Ag-specific immune responses.
Formula

C18H32O16
CAS 号
性状

固体

颜色

White to off-white

中文名称

昆布多糖；褐藻淀粉
结构分类
初始来源

Eisenia Bicyclis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : 16.67 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 33.33 mg/mL (Infinity mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (264 KB)

产品使用指南 (1538 KB)
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Laminaran9008-22-4昆布多糖褐藻淀粉OthersImmunomodulatingradioprotectiveanticancer immunotherapytumorInhibitorinhibitorinhibit

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目录号：
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