LH-RH (7-10) 

LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes^[3].

The formation of LHRH 4-10, LHRH 7-10, and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor), Thiorphan (HY-W013375) (an EP24.11 inhibitor), and Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor)^[3].
LH-RH (7-10) inhibits the binding of ¹²⁵I-labeled GnRH to monoclonal antibody P₈16₆₂ with an IC₅₀ value of 1.7 nM^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LH-RH (7-10) (i.v.) increases esterase activity in plasma kinin system in rats^[1].
LH-RH (7-10) (ntracarotid infusion i.v.; single dose) stimulates a significant increase in plasma LH concentration in the jugular vein^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

440.54

C₁₉H₃₆N₈O₄

38482-71-2

LRPG-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mandzhikyan, et al. Effect of luteinizing hormone releasing hormone fragments on the rat plasma kinin system. Russian. 1979; 69(2):115-118.

  [2]. Carlson JC, et al. The effect of LH-RH administration on LH release in the female rabbit. J Reprod Fertil. 1979 May;56(1):175-80.  [Content Brief]

  [3]. Yang X, et al. Enzymatic degradation of luteinizing hormone releasing hormone (LHRH)/[D-Ala6]-LHRH in lung pneumocytes. Pharm Res. 1998 Sep;15(9):1480-4.  [Content Brief]

  [4]. Talwar GP, et al. Bioeffective monoclonal antibody against the decapeptide gonadotropin-releasing hormone: reacting determinant and action on ovulation and estrus suppression. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1228-31.  [Content Brief]