LY 295427  (Synonyms: Agisterol)

LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research^[1][2][3].

LY 295427 时间依赖性地增加中国仓鼠卵巢 (CHO) 细胞对 25-OH chol 的摄取^[1]。
LY 295427 (2.9 μM) 提高 30% LDL 受体启动子的活性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LY 295427 剂量依赖性地降低胆固醇-椰子油喂养的仓鼠 LDL-R 转录水平，ED₅₀ 值为 40 mg/kg/day^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

428.73

C₃₀H₅₂O

152755-31-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bowling N, et al. LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. J Lipid Res. 1996 Dec;37(12):2586-98.  [Content Brief]

  [2]. George Chang, et al. Low density lipoprotein receptor up-regulation. Expert Opinion on Therapeutic Patents. Volume 9, 1999-Issue 5.

  [3]. Bensch WR, et al. Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters. J Pharmacol Exp Ther. 1999 Apr;289(1):85-92.  [Content Brief]