2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Margetuximab

Margetuximab 

目录号: HY-P99030 纯度: 98.90%
COA

摩尔计算器

Margetuximab (MGAH22) 是一种嵌合抗 HER2 单克隆抗体，具有优化的 Fc 结构域，EC50 为 39.33 ng/mL。Margetuximab 可用于转移性 HER2 阳性乳腺癌研究。

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Margetuximab Chemical Structure

Margetuximab Chemical Structure

CAS No. : 1350624-75-7

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7500
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Margetuximab 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Chimeric
IC50 & Target

EC50: 39.33 ng/mL (HER2)[1]
体外研究
(In Vitro)

Margetuximab (MGAH22) enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Margetuximab 相关抗体:

Cell Proliferation Assay

Cell Line: JIMT-1, MCF-7, ZR-75-1, SKBR-3, HT-29, SW750 and N87[1]
Concentration: 0.001-1000 ng/mL
Incubation Time: 6 days
Result: Enhances the antibody-dependent cell-mediated cytotoxicity activity of effector cells expressing the CD16A-158F variant.
体内研究
(In Vivo)

Margetuximab (2-4 mg/kg; IP 5 or 6 times at weekly) can firstly and significantly reduces the tumor size at day 30 - 37 in mice model[1].
Margetuximab (15-150 mg/kg; IV; 6 weekly) exhibits well tolerated in cynomolgus monkeys, decreases NK cells by an average of 51%, and induces IL-6 release[1].
Margetuximab (50 mg/kg; IV; single dosage) exhibits favorable safety profile[1].
Pharmacokinetic Parameters of Margetuximab in cynomolgus monkeys[1].

Male, IV (50 mg/kg) Female, IV (50 mg/kg)
Cmax (mg/mL) 1.62 ± 0.10 1.70 ± 0.14
AUC0-¥ (mg·hour/mL) 294.1 ± 53.2 314.2 ± 31.3
T1/2β (days) 9.3 ± 1.8 9.7 ± 1.1
Clearance (mL/hour) 0.43 ± 0.07 0.40 ± 0.04
VSS (mL) 132 ± 2 127 ± 8

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.90%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Margetuximab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Margetuximab1350624-75-7EGFREpidermal growth factor receptorErbB-1HER1HER2JIMT-1Cynomolgus monkeysAnticancerMetastatic HER2-positive breast cancerInhibitorinhibitorinhibit

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