1. Others
  2. Thyroid Hormone Receptor
  3. MB-07811

MB-07811 (Synonyms: VK-2809)

目录号: HY-111288
产品使用指南

MB-07811 (VK-2809) 是一种具有口服活性的 MB07344 的 HepDirect 前药,MB07344 是一种肝脏靶向甲状腺激素受体 β 激动剂。MB-07811 具有降低胆固醇和甘油三酯的活性。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

MB-07811 Chemical Structure

MB-07811 Chemical Structure

CAS No. : 852948-13-1

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 技术信息

  • 纯度 & 产品资料

  • 参考文献

Description

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2].

IC50 & Target

Thyroid hormone receptor-β[2]

In Vitro

MB-07811 (VK-2809) is potential for liver targeting with a low affinity for thyroid hormone receptors (TRβ Ki=14.6 ± 0.5 μM; TRα Ki=12.5 ± 0.6 μM)[2].

In Vivo

MB-07811 (VK-2809) (0.3-30 mg/kg; orally once daily for 14 days) reduces cholesterol and triglycerides in diet-induced obese mice[2].

Animal Model: 4-week-old male C57BL/6 mice (diet-induced obese (DIO) mice)[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Orally once daily; 14 days
Result: Reduced total plasma cholesterol, and reduced plasma triglycerides (40%) at the highest doses.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

514.98

Formula

C₂₈H₃₂ClO₅P

CAS No.

852948-13-1

SMILES

OC1=CC=C(CC2=C(C)C=C(OC[P@]3(OCC[C@@H](C4=CC=CC(Cl)=C4)O3)=O)C=C2C)C=C1C(C)C

Shipping

Room temperature in continental US; may vary elsewhere

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
MB-07811
目录号:
HY-111288
需求量:

MB-07811

Cat. No.: HY-111288