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  4. MB076

MB076 是一种改善血浆稳定性的新型杂环三唑，可抑制 7 种C类 Acinetobacter 衍生的 Cephalosporinases (ADCs) β-内酰胺酶变异体，其 Ki ＜ 1 μM。 MB076 与多种头孢菌素协同作用，恢复 pBCSK(−) 对多种 Cephalosporinases 的易感性。

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MB076 Chemical Structure

MB076 Chemical Structure

CAS No. : 2832966-95-5

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MB076 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with Ki values ＜ 1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(−) susceptibility[1].

IC50 & Target

Ki Target: ADC-7, ADC-30, ADC-162, ADC-33, ADC-219, ADC-212[1]
Ki: 0.21±0.016 μM (ADC-7), 0.058±0.005μM (ADC-30), 0.79±0.039μM (ADC-162), 0.10±0.004μM (ADC-33), 0.11±0.019 (ADC-219), 0.61±0.038μM (ADC-212)[1]
体外研究
(In Vitro)

MB076 (compound B) (0.5-5 μM, 48 h) 在人血浆中的稳定性有所提高[1]。
MB076 (10 μg/mL, 48 h) 与 Ceftazidime (CAZ HY-B0593)、 Cefotaxime (CTXHY-A0088A) 联合可协同恢复 pBCSK(−) 药敏[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MB076 相关抗体:

Cell Viability Assay[1]

Cell Line: Human Plasma
Concentration: 0.5 μM, 1 μM, 2.5 μM, 4 μM, 5 μM
Incubation Time: 48 h
Result: Showed excellent stability in human plasma, with a t1/2 value of 29 h, notably higher than the value obtained for ADC-7/S02030 (PDB4U0X) (9 h).
分子量

373.18

Formula

C9H12BN7O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MB076 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MB0762832966-95-5MB 076MB-076OthersInhibitorinhibitorinhibit

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HY-155011
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