2. Academic Validation
  3. Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor against 3T3-L1 adipocytes

Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor against 3T3-L1 adipocytes

  • Bioorg Med Chem Lett. 2009 Feb 1;19(3):867-9. doi: 10.1016/j.bmcl.2008.11.109.
Kenichiro Shimokawa 1,  Kaoru Yamada,  Daisuke Uemura
Affiliations

Affiliation

  • 1 Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
PMID: 19097891 DOI: 10.1016/j.bmcl.2008.11.109
Abstract

Based on the structural similarity between the naturally occurring cyclic heptapeptides rhizonin A and ternatin, two novel analogues were designed. The synthetic analogues were assessed with regard to their fat-accumulation inhibitory effect against 3T3-L1 adipocytes, and this led to the discovery of a potent and selective fat-accumulation inhibitor compared to the parent compound rhizonin A.

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