1. Academic Validation
  2. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway

Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway

  • Phytother Res. 2011 Jun;25(6):833-7. doi: 10.1002/ptr.3323.
Myung Sun Lee 1 Eun Young Cha Ji Young Sul In Sang Song Ji Yeon Kim
Affiliations

Affiliation

  • 1 Regional Cancer Institute, Chungnam National University Hospital, Daejeon 301-721, Republic of Korea.
Abstract

Inactivation of epidermal growth factor receptor (EGFR) is a prime method used in colon Cancer therapy. Here it is shown that chrysophanic acid, a natural anthraquinone, has Anticancer activity in EGFR-overexpressing SNU-C5 human colon Cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as Akt, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 µm) significantly blocked cell proliferation when combined with the mTOR Inhibitor, rapamycin. These findings offer the first evidence of Anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-13595
    99.77%, EGFR抑制剂