1. Academic Validation
  2. Influence of the lysine on the calcium oxalate renal calculi

Influence of the lysine on the calcium oxalate renal calculi

  • Int Urol Nephrol. 2014 Mar;46(3):593-7. doi: 10.1007/s11255-013-0532-x.
Stoyanka S Atanassova 1
Affiliations

Affiliation

  • 1 Department of Clinical Laboratory and Clinical Immunology, Medical University, 1431, Sofia, Bulgaria, stoyana_atanassova@abv.bg.
Abstract

Plasma levels and urinary excretions of amino acid lysine were estimated by high-performance liquid chromatography in 15 control subjects and 56 stone formers (SFs) with calcium oxalate (CaOX) urolithiasis. Data demonstrated clearly that there is a general tendency toward decreased lysine's excretions in above 40% of SFs. Moreover, it was found that DL-lysine, a normal physiological constituent of urine, acts at increased concentrations as a dissolving agent with respect to CaOX and CaOX calculi. The kinetics of dissolution of crystalline calcium oxalate calculi in physiological solutions containing DL-lysine at different concentrations is studied, using the change in the Archimedean weight of samples immersed in the solution. The possible effect of lysine as a natural regulator of CaOX supersaturation and crystallization in human urine is also discussed.

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