2. Academic Validation
  3. Structure and functions of angiotensinogen

Structure and functions of angiotensinogen

  • Hypertens Res. 2016 Jul;39(7):492-500. doi: 10.1038/hr.2016.17.
Hong Lu 1 2,  Lisa A Cassis 3,  Craig W Vander Kooi 4,  Alan Daugherty 1 2 3
Affiliations

Affiliations

  • 1 Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA.
  • 2 Department of Physiology, University of Kentucky, Lexington, KY, USA.
  • 3 Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
  • 4 Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.
PMID: 26888118 DOI: 10.1038/hr.2016.17
Abstract

Angiotensinogen (AGT) is the sole precursor of all angiotensin Peptides. Although AGT is generally considered as a passive substrate of the renin-angiotensin system, there is accumulating evidence that the regulation and functions of AGT are intricate. Understanding the diversity of AGT properties has been enhanced by protein structural analysis and animal studies. In addition to whole-body genetic deletion, AGT can be regulated in vivo by cell-specific procedures, adeno-associated viral approaches and Antisense Oligonucleotides. Indeed, the availability of these multiple manipulations of AGT in vivo has provided new insights into the multifaceted roles of AGT. In this review, the combination of structural and functional studies is highlighted to focus on the increasing recognition that AGT exerts effects beyond being a sole provider of angiotensin Peptides.

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