2. Academic Validation
  3. Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities

Quinazolinone and quinazoline derivatives: recent structures with potent antimicrobial and cytotoxic activities

  • Res Pharm Sci. 2016 Jan-Feb;11(1):1-14.
Elham Jafari 1,  Marzieh Rahmani Khajouei 2,  Farshid Hassanzadeh 1,  Gholam Hossein Hakimelahi 3,  Ghadam Ali Khodarahmi 1
Affiliations

Affiliations

  • 1 Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran; Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
  • 2 Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran; Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
  • 3 Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan.
PMID: 27051427
Abstract

The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like Antibacterial, Antifungal, anticonvulsant, anti-inflammatory, anti-HIV, Anticancer and analgesic activities. This skeleton is an important pharmacophore considered as a privileged structure. This review highlights the recent advances in the synthesis of quinazolines and quinazolinone derivatives with potent antimicrobial and cytotoxic activities.

Keywords

Antimicrobial; Cytotoxic; Quinazoline; Quinazolinones.

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