2. Academic Validation
  3. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective

Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective

  • Oxid Med Cell Longev. 2016;2016:2124638. doi: 10.1155/2016/2124638.
Yingke Zhao 1,  Yue Liu 2,  Keji Chen 2
Affiliations

Affiliations

  • 1 Cardiovascular Diseases Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China; School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
  • 2 Cardiovascular Diseases Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
PMID: 27668034 DOI: 10.1155/2016/2124638
Abstract

Tetramethylpyrazine, a natural compound from Ligusticum wallichii (Chuan Xiong), has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystems, especially in cardiovascular, its pharmacological action, clinical application, and the structural modification have attracted broad attention. In this paper its mechanisms of action, the clinical status, and synthetic derivatives will be reviewed briefly.

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