2. Academic Validation
  3. MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation

MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation

  • Biochem Biophys Res Commun. 2021 May 21;554:63-70. doi: 10.1016/j.bbrc.2021.02.146.
Bin Zhang 1,  Jun Xiao 1,  Xiang Cheng 2,  Tao Liu 3
Affiliations

Affiliations

  • 1 Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • 2 Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: squall4453@163.com.
  • 3 Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: uniontao@hust.edu.cn.
PMID: 33780861 DOI: 10.1016/j.bbrc.2021.02.146
Abstract

Pancreatic Cancer is a digestive tract malignancy characterized by an occult onset and rapid progression. The genetic heterogeneity of pancreatic Cancer is closely related to its highly malignant biological behavior. The myelin and lymphocyte protein 2 (MAL2) is upregulated in multiple cancers at the transcriptional level. However, the exact role of MAL2 in pancreatic Cancer remains elusive. In this study, we demonstrated that MAL2 protein and mRNA levels were upregulated in pancreatic Cancer. MAL2 overexpression was significantly associated with poor prognosis in patients with pancreatic Cancer. We further showed that MAL2 interacted with IQGAP1 to increase ERK1/2 phosphorylation levels, which promoted pancreatic Cancer progression. Therefore, these results suggest that MAL2 could be a novel therapeutic target for pancreatic Cancer.

Keywords

ERK; IQGAP1; MAL2; Pancreatic cancer.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-15947
    99.75%, ERK抑制剂
    ERK
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