Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract

Affiliations

• 1 Department of Food Science, University of Massachusetts, Amherst, MA, USA.
• 2 Departments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• 3 State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China.
• 4 Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao, China.
• 5 Massachusetts Host-Microbiota Center, Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
• 6 Department of Medicine and Department of Health Research and Policy, Stanford University, Stanford, CA, USA.
• 7 School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
• 8 Department of Entomology and Nematology, University of California, Davis, CA, USA.
• 9 Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA, USA.
• 10 Department of Mathematics and Statistics, University of Massachusetts, Amherst, MA, USA.
• 11 Eastern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Wyndmoor, PA, USA.
• 12 Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
• 13 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• 14 Department of Cell Biology and Physiology, and Department of Otolaryngology, Washington University, St. Louis, MO, USA.
• 15 Department of Cell Biology and Physiology, Institute for Informatics, Washington University, St. Louis, MO, USA.
• 16 State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China. zwcai@hkbu.edu.hk.
• 17 Departments of Chemistry, Biochemistry, Microbiology and Genomics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. redinbo@unc.edu.
• 18 Department of Food Science, University of Massachusetts, Amherst, MA, USA. zhanggd@nus.edu.sg.
• 19 Department of Food Science and Technology, National University of Singapore, Singapore, Singapore. zhanggd@nus.edu.sg.
• # Contributed equally.