The in vitro effect of new combinations of carbapenem-β-lactamase inhibitors for Mycobacterium abscessus

As new treatment alternatives for Mycobacterium abscessus complex (MABC) are urgently needed, we determined the minimum inhibitory concentrations (MICs) for novel carbapenem combinations, including imipenem-relebactam and tebipenem-avibactam against 98 MABC isolates by broth microdilution. The MIC50 was reduced from 16 to 8 mg/L by adding relebactam to imipenem, while the addition of avibactam to tebipenem showed a more pronounced reduction from 256 to 16 mg/L, representing a promising non-toxic, oral treatment option for further exploration.

difficult to treat NTMs; imipenem-relebactam; minimum inhibitory concentrations; new treatment alternatives; tebipenem-avibactam; β-lactam antibiotics; β-lactamase inhibitors.