2. Academic Validation
  3. Preparation and cytotoxic effect of ceanothic acid derivatives

Preparation and cytotoxic effect of ceanothic acid derivatives

  • J Nat Prod. 1998 Nov;61(11):1343-7. doi: 10.1021/np9800856.
S S Lee 1,  W C Chen,  C F Huang,  Y Su
Affiliations

Affiliation

  • 1 School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China. shoeilee@ha.mc.ntu.edu.tw
PMID: 9834149 DOI: 10.1021/np9800856
Abstract

Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa Cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.

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