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MCTR3 是一种促溶解的 maresin 偶联物，可以减少炎症反应并且促进组织再生。MCTR3 可以改善 LPS 诱导的急性肺损伤和关节炎。

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MCTR3 Chemical Structure

MCTR3 Chemical Structure

CAS No. : 1784701-63-8

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MCTR3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MCTR3 is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes the tissue regeneration. MCTR3 exhibits potency in ameliorating LPS-induced acute lung injury and arthritis[1][2][3].

体外研究
(In Vitro)

MCTR3 (1 nM) 可通过 ALX/PINK1 通路缓解 MLE12 细胞中 LPS 诱导的细胞损伤和氧化应激，减少细胞凋亡 (apoptosis) 和自噬 (autophagy) 相关蛋白的产生[1]。
MCTR3 (1 nM) 增强渗出白细胞的胞吞作用和细菌吞噬作用，减少中性粒细胞浸润和类二十烷酸水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MCTR3 相关抗体:

Immunofluorescence[1]

Cell Line: MLE12
Concentration: 1 nM
Incubation Time: 24 h
Result: Decreased LPS-stimulated expressions of PINK1 and Parkin.

Western Blot Analysis[1]

Cell Line: MLE12
Concentration: 1 nM
Incubation Time: 24 h
Result: Decreased levels of Bax, Bak, Cyto C and LC3BII/I, increased levels of BCL2 and Bcl-xl.
体内研究
(In Vivo)

MCTR3 (2 ng/g，腹腔注射，单剂量) 可缓解 C57BL/6 小鼠中 LPS 诱导的急性肺损伤，改善炎症和氧化反应，并减少细胞凋亡 (apoptosis)[1]。
MCTR3 (1-100 nM，在冷水中) 以剂量依赖的方式刺激手术损伤的涡虫组织再生，50% 组织再生 (TRI50) 需要 2.5 天[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lipopolysaccharide induced acute lung injury in C57BL6 mice[1]
Dosage: 2 ng/g
Administration: i.p., single dose
Result: Reduced inflammatory cell infiltration and protein accumulation in bronchoalveolar lavage fluid (BALF), reduced MDA levels and increased SOD activity in lung tissue.
Decreased levels of pro-inflammatory cytokine in serum.
Animal Model: Surgical injury in Planaria[2]
Dosage: 1-100 nM
Administration: In cold water for 6 days
Result: Accelerated tissue regeneration in a dose-dependent manner with a TRI50 of 2.5 days.
分子量

463.63

Formula

C25H37NO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MCTR3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCTR31784701-63-8MCTR 3MCTR-3OtherslipopolysaccharideLPSC57BL/6 miceFVB miceDBA-1 micepulmonary epithelial cell lineMLE-12PMNInhibitorinhibitorinhibit

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目录号：
HY-125516
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