2. Apoptosis
  3. TNF Receptor
  4. Mitazalimab

Mitazalimab  (Synonyms: ADC-1013; JNJ-64457107)

目录号: HY-P99742 纯度: 98.74%
COA

摩尔计算器

Mitazalimab (ADC-1013; JNJ-64457107) 是 FcγR 依赖性 CD40 激动剂，具有肿瘤导向活性。Mitazalimab 激活抗原呈递细胞，例如 树突状细胞 (DC)，以启动肿瘤反应性 T 细胞。因此，Mitazalimab 诱导肿瘤特异性 T 细胞浸润并杀死肿瘤。Mitazalimab 可重塑肿瘤浸润性骨髓微环境。

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Mitazalimab Chemical Structure

Mitazalimab Chemical Structure

CAS No. : 2055640-86-1

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5 mg ￥7800
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Mitazalimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment[1][2].

同型

Human IgG1 lambda1
推荐同型对照抗体
种属

Humanized
IC50 & Target[1][2]

CD40

 

体外研究
(In Vitro)

Mitazalimab（1 ng/mL-10 μg/mL）可激活人类前列腺肿瘤或卵巢肿瘤样本中的肿瘤相关巨噬细胞 (TAM)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mitazalimab 相关抗体:
体内研究
(In Vivo)

Mitazalimab（100 μg/小鼠；腹腔注射；单次剂量）激活 naïve hCD40tg 小鼠的脾脏树突细胞和 B 细胞，并在 OVA 再处理条件（200 μg；i.v.；3 次，连续 7 天）下，导致 OVA 特异性 CD8+ T 细胞扩增[1]。
Mitazalimab（100 和 300 μg/小鼠；腹腔注射；接种后第 7、10 和 13 天）诱导携带 MB49（小鼠膀胱肿瘤细胞系）的肿瘤小鼠的血液中促炎细胞因子和趋化因子的释放，并改变肿瘤骨髓细胞组成，减少单核细胞和巨噬细胞，增加粒细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MB49-tumor bearing mice model[1]
Dosage: 10, 30, 100 or 300 µg/mouse
Administration: Intraperitoneal injection; on day 7, 10 and 13 post-inoculation; sampled at 24 h after final dose
Result: Increased the level of IP-10, MIP-1α and TNF-α, but not CXCL1, IFN-γ, IL-6, IL-10, MCP-1 and MIP-2.
Resulted in increased frequency of CD44hi CD62L-efector memory CD8+ and CD4+ T cells.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.74%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Mitazalimab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitazalimab2055640-86-1ADC-1013 JNJ-64457107ADC1013ADC 1013JNJ64457107JNJ 64457107JNJ-64457107TNF ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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