2. Apoptosis Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Glutathione Peroxidase Potassium Channel
  4. MPO-IN-5

MPO-IN-5 (化合物 1) 是一种有效的、不可逆的 MPO (髓过氧化物酶)抑制剂。MPO-IN-5 抑制 MPO 过氧化作用和 hERG 结合，IC50 值分别为 0.22 和 2.8 μM。MPO-IN-5 表现出快速的抑制动力学，酶失活率 (kinact/Ki) 为 23000 M−1s−1。

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MPO-IN-5 Chemical Structure

MPO-IN-5 Chemical Structure

CAS No. : 2476764-11-9

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MPO-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].

IC50 & Target

IC50: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO)[1]
分子量

428.49

Formula

C24H24N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MPO-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPO-IN-52476764-11-9Glutathione PeroxidasePotassium ChannelKcsAperoxidaseperoxidationmyeloperoxidaseMPOTPOindoleIrreversibleMechanism-based inhibitorhuman ether-a-go-go-related genehERGpotassium channelInhibitorinhibitorinhibit

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目录号：
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