2. Neuronal Signaling NF-κB Immunology/Inflammation Apoptosis GPCR/G Protein MAPK/ERK Pathway
  3. Cholinesterase (ChE) NF-κB Interleukin Related TNF Receptor CCR NOD-like Receptor (NLR) JNK NO Synthase
  4. MR2938

MR2938 是一种有效的 AChE 抑制剂，IC50 为 5.04 μM。 MR2938 也明显抑制 NO 的产生 (IC50 = 3.29 μM)。 MR2938 通过阻断 MAPK/JNK 和 NF-κB 信号通路抑制神经炎症。 MR2938 可用于阿尔茨海默病 (AD) 研究。

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MR2938 Chemical Structure

MR2938 Chemical Structure

CAS No. : 1044870-65-6

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MR2938 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 CCR 亚型特异性产品:

查看所有亚型
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target

AChE

5.04 ± 0.7 μM (IC50)

BChE

>20 μM (IC50)

NF-κB

 

IL-1β

 

IL-6

 

NLRP3

 

JNK

 

体外研究
(In Vitro)

MR2938 (0-10 μM, 24 h) 在 1.25 μM 时降低促炎细胞因子 IL-1β、TNF-α、IL-6 和 CCL2 的 mRNA 水平[1]。
MR2938 (10 μM, 24 h) 阻断 LPS 诱导的 BV-2 细胞中的 NF-κB 信号通路[1]。
MR2938 (20 μM) 对 AChE 和 BChE 具有抑制活性，抑制率分别为 91.8 ± 2.68% 和 38.7 ± 11.7%[1]。
MR2938 (0-10 μM) 对 BV2 细胞系的细胞活力影响很小[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MR2938 相关抗体:

RT-PCR[1]

Cell Line: BV-2 cells
Concentration: 0, 1.25, 2.5, 5, and 10 μM
Incubation Time: 24 h
Result: Dramatically and dose dependently reduced the mRNA levels of inflammatory factors stimulated by LPS (1 μg/mL). Compared with TNF-α, the inhibitory effect of MR2938 on IL-1β, IL-6 and CCL2 was much potent.

Western Blot Analysis[1]

Cell Line: BV-2 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Suppressed the expression level of p65 protein, and reduced the p-p65 level. Reduced NLRP3 expression obviously. Reduced the phosphorylation level of JNK induced by LPS stimulation, while the level of JNK protein was hardly changed.
分子量

380.44

Formula

C21H24N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MR2938 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MR29381044870-65-6MR 2938MR-2938Cholinesterase (ChE)NF-κBInterleukin RelatedTNF ReceptorCCRNOD-like Receptor (NLR)JNKNO SynthaseNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRCC chemokine receptorc-Jun N-terminal kinaseNitric oxide synthasesNOSQuinazolin-4(3H)-oneAcetylcholinesteraseButyrylcholinesteraseanti-inflammatory activityMultifunctional inhibitorAlzheimer’s diseaseInhibitorinhibitorinhibit

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