2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. MRS 1477

MRS 1477 是一种二氢吡啶衍生物，在辣椒素存在下是 TRPV1 的正变构调节剂。MRS 1477 本身不诱导细胞凋亡，但 MRS 1477 与辣椒素共存可诱导细胞凋亡。

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MRS 1477 Chemical Structure

MRS 1477 Chemical Structure

CAS No. : 212200-21-0

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MRS 1477 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis[1][2].

体外研究
(In Vitro)

MRS1477 在 MCF7 乳腺癌细胞中激发 Ca2+ 信号，但在原代乳腺上皮细胞中没有[1]。
MRS1477 (2 μM; 72 h) 与 capsaicine (10 μM) 一起诱导细胞凋亡并增加活性氧的产生和半胱天冬酶活性[1]。
MRS1477 (2 μM) 增加 capsaicine 诱发的 TRPV1 介导的电流密度水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MRS 1477 相关抗体:
分子量

389.51

Formula

C21H27NO4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MRS 1477 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS 1477212200-21-0MRS1477MRS-1477TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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HY-110145
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