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  4. N,N'-Dimethylhydrazine dihydrochloride

N,N'-Dimethylhydrazine dihydrochloride  (Synonyms: 1,2-Dimethylhydrazine dihydrochloride)

目录号: HY-W460407
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N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride 是一种肿瘤诱导剂，可在啮齿类动物身上诱导出结肠瘤。

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N,N'-Dimethylhydrazine dihydrochloride Chemical Structure

N,N'-Dimethylhydrazine dihydrochloride Chemical Structure

CAS No. : 306-37-6

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N,N'-Dimethylhydrazine dihydrochloride 相关抗体

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  • 生物活性

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生物活性

N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride is a tumor inducer that induces colon tumors in rodents[1][2].

体内研究
(In Vivo)

N,N'-Dimethylhydrazine (DMH) (20 mg/kg; sc; 每周一次, 24 wk) 可在 ICR 小鼠体内诱导结肠癌[1]。
N,N'-Dimethylhydrazine (20 mg/kg; sc; 20 wk) 在大鼠腹腔内诱导肠癌肿瘤，这种作用会被嗜酸乳杆菌有效抑制。食用模拟“西方”饮食的牛肉饮食的老鼠比谷物喂养的老鼠患结肠癌的几率更高 (分别为 83% 和 31%)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mouse[1]
Dosage: 20 mg/kg
Administration: sc; once weekly for 24 weeks; sacrificed mouse after between 23 and 33 weeks.
Result: Induced colon cancer in ICR mice.
Animal Model: Male inbred F344 rats[1]
Dosage: 20 mg, 4 mg/mL dissolved in normal saline containing 1.5% EDTA (pH 6.4 and filter sterilized)
Administration: sc; weekly for 20 or 35 weeks
Result: Produced a higher incidence of adenocarcinomas in the small and large intestines of animals that were consuming the meat diet.
分子量

133.02

Formula

C2H10Cl2N2
CAS 号
性状

固体

中文名称

N,N'-二甲基肼二盐酸盐； 1,2-二甲基肼二盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

N,N'-Dimethylhydrazine dihydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N'-Dimethylhydrazine306-37-61,2-DimethylhydrazineN,N'-二甲基肼二盐酸盐 1,2-二甲基肼二盐酸盐Biochemical Assay Reagentstumor inducerInhibitorinhibitorinhibit

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