2. Immunology/Inflammation
  3. Interleukin Related
  4. Nadunolimab

Nadunolimab 

目录号: HY-P99235 纯度: 98.11%
COA

摩尔计算器

Nadunolimab 是一种靶向 IL1RAP 的人 IgG1 单克隆抗体。Nadunolimab 阻断 IL-1α 和 IL-1β 信号并触发抗体依赖性细胞毒性。Nadunolimab 可用于癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Nadunolimab Chemical Structure

Nadunolimab Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3900
In-stock
5 mg ￥9750
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Nadunolimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nadunolimab is a human monoclonal IgG1 antibody targeting IL1RAP. Nadunolimab blocks IL-1α and IL-1β signaling and triggering antibody-dependent cellular cytotoxicity. Nadunolimab can be used in research of cancer[1].

IC50 & Target

IL-1α

 

IL-1β

 

体外研究
(In Vitro)

Nadunolimab (20 µg/mL; 30 min and 1 h; A549 cells and BxPC3 cells) reduces IL-1α-induced release of pro-infamma tory cytokines and chemokines, including IL-1β, IL-6 TNF-α and MIP-1α, and CXCL1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nadunolimab 相关抗体:
体内研究
(In Vivo)

Nadunolimab (10 mg/kg; i.p.; twice on day 1 and thereafter twice weekly; nude BALB/c mice with LU2503 or MC38 tumors) improves the anti‑tumor efficacy of chemotherapy and blocks both murine IL-1α and IL-1β signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude BALB/c mice with LU2503 or MC38 tumors[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; twice on day 1 and thereafter twice weekly
Result: Reduced tumor volume in combination with Cisplatin (HY-17394) and Gemcitabine (HY-17026).
Blocked both murine IL-1α and IL-1β signaling.
Clinical Trial
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nadunolimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NadunolimabInterleukin RelatedILIgG1 antibodyhumanized monoclonal antibodyantibody-dependent cellular cytotoxicityanticancerA549 cellsBxPC3 cellsCisplatinGemcitabineInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Nadunolimab
目录号：
HY-P99235
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z