2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NDT-30805

NDT-30805 是一种选择性的 NLRP3 inflammasome 抑制剂。NDT-30805 是一种三唑吡啶酮衍生物，可抑制 PBMC 中 IL-1β 的释放，其 IC50 值为 0.013 μM。NDT-30805 可用于炎症和免疫的研究。

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NDT-30805 Chemical Structure

NDT-30805 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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NDT-30805 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC50 of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity[1].

IC50 & Target

NLRP3

 

NLRP3 inflammasome

 

体外研究
(In Vitro)

NDT-30805 (0-2 μM; 30 min) inhibits IL-1β release in PBMCs[1].
NDT-30805 (0-2 μM; 30 min) inhibits ASC speck formation in THP1-ASC-GFP cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NDT-30805 相关抗体:

Cell Viability Assay[1]

Cell Line: Human PBMCs
Concentration: 0-2 μM
Incubation Time: 30 min
Result: Inhibited IL-1β release in PBMCs with an IC50 of 0.013 μM.

Cell Viability Assay[1]

Cell Line: THP1-ASC-GFP cells
Concentration: 0-2 μM
Incubation Time: 30 min
Result: Inhibited ASC which is a component of NLRP3 inflammasome in PBMCs with an IC50 of 0.034 μM.
分子量

414.53

Formula

C23H22N6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NDT-30805 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDT-30805NDT30805NDT 30805NOD-like Receptor (NLR)inflammasomeinterleukin-1inflammationinnate immunityInhibitorinhibitorinhibit

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产品名称：
NDT-30805
目录号：
HY-150965
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