2. Immunology/Inflammation
  3. Interleukin Related
  4. Nidanilimab

Nidanilimab  (Synonyms: CAN04; Anti-IL-1RAP/IL-1R3 Reference Antibody (nidanilimab))

目录号: HY-P99379 纯度: 99.90%
COA

摩尔计算器

Nidanilimab (CAN04) 是一种完全人源化的单克隆抗 IL1RAP 抗体，其 Kd 值为 1.10 pM。Nidanilimab 阻断 IL1α 和 IL1β 信号通路，并刺激免疫系统破坏肿瘤细胞。Nidanilimab 可用于非小细胞肺癌 (NSCLC) 和胰腺导管腺癌 (PDAC) 的研究。

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Nidanilimab Chemical Structure

Nidanilimab Chemical Structure

CAS No. : 2171061-85-9

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥9100
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Customer Review

Nidanilimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nidanilimab (CAN04) is a fully humanized monoclonal anti-IL1RAP antibody with a Kd value of 1.10 pM. Nidanilimab blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) [1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target[2]

IL-1α

 

IL-1β

 

体外研究
(In Vitro)

Nidanilimab (CAN04; 20 µg/mL; 小鼠 MC38 结肠癌细胞) 具有糖工程介导增强的抗体依赖性细胞毒性 (ADCC, EC50<1 nM)[2]。
Nidanilimab (20 µg/mL; 小鼠 MC38 结肠癌细胞) 阻断 IL1α 和 IL1β 信号通路，IC50 值分别为 3.9 nM和 4.1 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nidanilimab 相关抗体:
体内研究
(In Vivo)

Nidanilimab (CAN04; 10 mg/kg; i.p.; 裸 C57Bl/6 小鼠) 增加了两种常用的铂基化疗药物顺铂 (HY-17394)/吉西他滨 (HY-17026) 和卡铂 (HY-17393)/吉西他滨 (HY-17026) 的疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude C57Bl/6 mice with LU2503 NSCLC PDX model[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection
Result: Displayed a significantly stronger anti-tumor effect compared to isotype control with chemotherapy.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nidanilimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nidanilimab2171061-85-9CAN04 Anti-IL-1RAP/IL-1R3 Reference Antibody (nidanilimab)CAN 04CAN-04Interleukin RelatedILhumanized monoclonal antibodyimmune systemnon-small lung cancerpancreatic ductal adenocarcinomamurine MC38 colon cancer cellsInhibitorinhibitorinhibit

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