NNMT-IN-4 

NNMT-IN-4 (compound 38) is a selective, uncompetitive and membrane permeability nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀ values of 42 and 38 nM in vitro biochemical and cell-based assays, respectively. NNMT-IN-4 shows favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. NNMT-IN-4 can be used as a vivo chemical probe of NNMT^[1].

IC50: 38 nM (NNMT, in K562 cells), 42 nM (promega MTase-Glo methyltransferase assay)^[1]

NNMT-IN-4 (5 nM-0.5 mM; 24 h) shows inhibitory effect to NNMT with an IC₅₀ value of 38 nM in K562 cells^[1].
NNMT-IN-4 (5 nM-0.5 mM; 24 h) shows inhibitory effect to NNMT with an IC₅₀ value of 42 nM in promega MTase-Glo methyltransferase assay^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pharmacokinetic Properties of NNMT-IN-4 in Mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

177.20

C₉H₁₁N₃O

2947393-64-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Barrows RD, et al. Potent Uncompetitive Inhibitors of Nicotinamide N-Methyltransferase (NNMT) as In Vivo Chemical Probes. J Med Chem. 2022 Nov 10;65(21):14642-14654.  [Content Brief]