2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. OHM1

OHM1 是 HIF1α CTAD 的类似物，抑制其与 p300/CBP 的结合。OHM1 靶向 CH1 结构域，亲和力为 0.53 μM。

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OHM1 Chemical Structure

OHM1 Chemical Structure

CAS No. : 1450995-09-1

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OHM1 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OHM1 is an analog of HIF1α CTAD that inhibits its binding with p300/CBP. OHM1 targets CH1 domain with an affinity of 0.53 μM[1].

体外研究
(In Vitro)

OHM1 (1-20 μM; 24 h) 导致 HIF 启动子活性呈剂量依赖性降低，并在 20 μM 使 MDA-MB-231 细胞在低氧条件下的 HIF1α 转录活性降低至常氧条件下[1].
OHM1 下调缺氧诱导基因表达[1]。
OHM1 (10 μM) 下调了 A549 非小细胞肺癌细胞系中与血管生成、凋亡、细胞增殖和侵袭相关的多个基因，以及几种癌症特异性标记物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OHM1 相关抗体:

RT-PCR[1]

Cell Line: A549
Concentration: 10 μM
Incubation Time: 24 h
Result: Down-regulated the mRNA expression levels of the critical angiogenesis regulator vascular endothelial growth factor (VEGFA) by 80%. Decreased lysyl oxidase (LOX) and glucose transporter 1 (GLUT1) expression.
体内研究
(In Vivo)

OHM1 (15 mg/kg; i.p.; every other day for 15 injections) 降低小鼠 MDA-MB-231 肿瘤体积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice, MDA-MB-231 xenograft model[1]
Dosage: 15 mg/kg
Administration: Intraperitoneal injection, every other day for 15 injections
Result: Reduced the median tumor volume by roughly 50% compared with the untreated group. Did not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals, nor increased the metastasis rate.
分子量

494.63

Formula

C24H42N6O5
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OHM1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OHM11450995-09-1OHM 1OHM-1HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHMDA-MB-231A549BALB/cVEGFALOXGLUT1Inhibitorinhibitorinhibit

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