2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. OX2R-IN-1

OX2R-IN-1(compound 15) 是一种 OX2R 拮抗剂(一种潜在的 OX2R 结合剂) ，具有低细胞毒性，IC50值为 484 μM。OX2R-IN-1 可穿过血脑屏障，活性分子半衰期短。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

OX2R-IN-1 Chemical Structure

OX2R-IN-1 Chemical Structure

CAS No. : 2639148-08-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

OX2R-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OX2R-IN-1 (compound 15) is a low cytotoxicity profile OX2R-IN-1 antagonist (a potential OX2R binder) with an IC50 value of 484 μM. OX2R-IN-1 (compound 15) can cross the BBB into the brain with a short half-life[1].

IC50 & Target

OX2 Receptor

 

体外研究
(In Vitro)

OX2R-IN-1 (compound 15) has low cytotoxic withIC50 values of 484 μM. OX2R-IN-1 (compound 15) is significant and dose-dependently reduce the signal of orexin A-evoked response (0.2 μM) in CHO-K1 cell line. OX2R-IN-1 (compound 15) has uncertain permeation through the BBB, since the PAMPA assay is limited by several drawbacks[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OX2R-IN-1 相关抗体:

Cell Cytotoxicity Assay[1].

Cell Line: CHO-K1 cell line
Concentration: 100-1000 µM
Incubation Time: 24h
Result: Exhibited low cytotoxic with IC50values of 484 μM
体内研究
(In Vivo)

OX2R-IN-1 (compound 15) has a short half-life and poor bioavailability.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino male Wistar rats[1]
Dosage: 75 mg/kg
Administration: OX2R-IN-1 (75 mg/kg; intraperitoneal injection) blood samples are collected at 0, 5, 10, 20, 30, 40, 60, 90, 120 and 240 min with a short half-life and poor bioavailability
Result: .......
Parameter Units Plasma Brain tissuer
t1/2,β (h)t1/2 min 9.63 14.85
tmax min 5 40
Cmax μmol/L 29.40 0.199
AUC μmol/L*min 1362.68 18.51
MRT min 39.94 68.93
分子量

457.97

Formula

C20H28ClN3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OX2R-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OX2R-IN-12639148-08-4Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorOrexin 2 receptor antagonistnervous systemsCHO-K1Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
OX2R-IN-1
目录号：
HY-149014
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z