2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Phenazopyridine

Phenazopyridine 是竞争性的 SARM1 抑制剂， IC50 为 145 μM。Phenazopyridine 是 TRPM8 拮抗剂。Phenazopyridine 具有局部麻醉/止痛作用。Phenazopyridine 用于缓解膀胱炎和尿道炎等疾病的疼痛症状。Phenazopyridine 能促进神经元分化，还可以用于创伤性脑损伤、周围神经病变和神经退行性疾病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Phenazopyridine Chemical Structure

Phenazopyridine Chemical Structure

CAS No. : 94-78-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
100 mg ￥6480
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Phenazopyridine:

Phenazopyridine 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases[1][2][3][4][5].

IC50 & Target

EC50: 145 μM (SARM1)[1].
体外研究
(In Vitro)

Phenazopyridine (10-30 μM; 12 h) 在人 SHSY5Y 和小鼠 N2a 细胞中均增加了 RPS23RG1 的 mRNA 的表达[2]。
Phenazopyridine (5-50 μM; 2 分钟) 在 HEK293 细胞中以浓度依赖和可逆的方式抑制薄荷醇 ( 50 μM) 诱导的 TRPM8 反应，IC50 值为9.6 μM[4]。
Phenazopyridine hydrochloride(3 μM; 6 周) 在人胚胎干细胞中能促进神经元分化[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Phenazopyridine 相关抗体:

Cell Differentiation Assay[5].

Cell Line: Human ES cells
Concentration: 3 μM
Incubation Time: 6 weeks
Result: After 10 weeks formed a neural network in the cells.

RT-PCR[5].

Cell Line: Human ES cells
Concentration: 3 μM
Incubation Time: 6 weeks
Result: Accelerated emergence of early neuronal markers and decreased markers of undifferentiated and non-neural cells.
体内研究
(In Vivo)

Phenazopyridine (15 m/kg; 侧脑室注射; 一天一次连续 2 周) 通过促进 Rps23rg1 的表达来改善阿尔兹海默症 (AD) APP/PS1小鼠的一些 AD 相关认知障碍和病理[2]。
Phenazopyridine (0.1-3 mg/kg; 静脉注射；单剂量) 能抑制 Sprague–Dawley 大鼠中机械敏感的 Aδ-纤维，而对 C-纤维无抑制作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice model of Alzheimer's disease< sup>[2]
Dosage: 15 mg/kg
Administration: Intraperitoneal injection (i.p.); Once daily for 2 weeks
Result: Increased the RPS23RG1 levels in lungs, liver and kidneys of mice.
Animal Model: APP/PS1 mice model of Alzheimer's disease[2]
Dosage: 15 mg/kg
Administration: Intracerebroventricularly injection; Once daily for 2 weeks
Result: Significantly reduced amyloid plaques.
Increased protein levels of RPS23RG1, PSD-95, and phosphorylated/inactivated GSK-3β, though without affecting levels of tau, phosphorylated tau, and p35.
Clinical Trial
分子量

213.24

Formula

C11H11N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Phenazopyridine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenazopyridine94-78-0TRP ChannelTransient receptor potential channelsSHSY5YN2aCystitisUrethritisUrinary bladderAnalgesiaAlzheimer's diseaseTraumatic brain injuryPeripheral neuropathyNeurodegenerative diseasesHEK293Neuronal differentiationHuman embryonic stem cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Phenazopyridine
目录号：
HY-B0985A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z