2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kδ-IN-12

PI3Kδ-IN-12 (化合物 13) 是一种 PI3Kδ 抑制剂 (pIC50 = 5.8)，其对 PI3Kδ/γ/β/α 的 pKi 值分别为 8.0/6.5/6.4/6.7。PI3Kδ-IN-12 可用于慢性呼吸系统疾病如哮喘和慢性阻塞性肺病 (COPD) 的研究。

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PI3Kδ-IN-12 Chemical Structure

PI3Kδ-IN-12 Chemical Structure

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PI3Kδ-IN-12 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3Kδ-IN-12 (compound 13) is a PI3Kδ inhibitor (pIC50 = 5.8), with pKi values of 8.0/6.5/6.4/6.7 for PI3Kδ/γ/β/α, respectively. PI3Kδ-IN-12 can be used in the study of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD)[1].

IC50 & Target[1]

PI3Kδ

5.8 (pIC50)

PI3Kδ

8.0 (pKi)

PI3Kγ

6.5 (pKi)

PI3Kβ

6.4 (pKi)

PI3Kα

6.7 (pKi)

分子量

444.27

Formula

C20H15Cl2N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3Kδ-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-12PI3KPhosphoinositide 3-kinaseCOPDasthmachronic respiratory diseasesInhibitorinhibitorinhibit

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产品名称：
PI3Kδ-IN-12
目录号：
HY-149235
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