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  4. (+)-EMD 57033

(+)-EMD 57033 是一种心肌肌钙蛋白 C (cTnC) 激活剂，是一种显性的 Ca2+ 敏化剂。(+)-EMD 57033 结合心脏/慢骨肌钙蛋白 C 亚型，发挥心肌收缩促进功能。

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(+)-EMD 57033 Chemical Structure

(+)-EMD 57033 Chemical Structure

CAS No. : 147527-31-9

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规格 价格 是否有货 数量
1 mg ￥3995
1 周
5 mg   询价  
10 mg   询价  

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Customer Review

(+)-EMD 57033 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function[1].

IC50 & Target

Cardiac troponin C (cTnC)[1]
体外研究
(In Vitro)

(+)-EMD 57033 (30 μM) recovers the activation and sensitivity of Ca2+ in pig single muscle fibres and reduces VIDD (ventilator-induced diaphragm muscle fibre dysfunction) of [2].
(+)-EMD 57033 (5.0-5.8 μM; 10-15 min) significantly increases the coronary blood flow and myocardial V̇o2 (O2 consumption) in both 100 bpm and 150 bpm heart rates of rabbit heart, with a [Ca2+]0 concentration-dependent manner ([Ca2+]0=1.0 or 2.5 mM)[3].
(+)-EMD 57033 (5.0-5.8 μM; 10-15 min) increases left ventricular (LV) end-diastolic pressure and prolongs relaxation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-EMD 57033 相关抗体:
体内研究
(In Vivo)

(+)-EMD 57033 (0.4 or 0.8 mg/kg/min; i.v.drip; over than 20 min) enhances contractility and achieves Ca2+ sensitization in intact failing hearts at substantial energetic savings and without compromise of diastolic function in dogs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mongrel dogs implanted with a micromanometer in left ventricle (LV) at the apex via lateral thoracotomy[4]
Dosage: 0.4 or 0.8 mg/kg/min
Administration: Intravenous drip; infused over 20 minutes
Result: Enhanced contractility at both doses, with similar changes in CON (conscious dogs) and HF (heart failure dogs) hearts.
Decreased the end-diastolic pressure (EDP) and lowered arterial load or preload at 0.8 mg/kg/min.
分子量

425.50

Formula

C22H23N3O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

(+)-EMD 57033 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-EMD 57033147527-31-9Othersventilator-induced diaphragm muscle fibre dysfunctionVIDDleft ventricularLVcontractilityenergetic savingdiastolic functionInhibitorinhibitorinhibit

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目录号：
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