2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Immunology/Inflammation
  3. PPAR Glucocorticoid Receptor
  4. PPARγ/GR modulator 1

PPARγ/GR modulator 1 是一种口服活性的 PPARγ 和糖皮质激素受体 (GR) 的双动激动剂，Ki 值分别为 3.3 和 33.6 μM。PPARγ/GR modulator 1 可用于研究代谢疾病，例如糖尿病。

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PPARγ/GR modulator 1 Chemical Structure

PPARγ/GR modulator 1 Chemical Structure

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PPARγ/GR modulator 1 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with Kis of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes[1].

IC50 & Target[1]

PPARγ

3.3 μM (Ki)

glucocorticoid receptor

33.6 μM (Ki)

体外研究
(In Vitro)

PPARγ/GR modulator 1 (化合物 11) 刺激 hBM-MSCs 中脂联素和瘦素分泌，IC50 值分别为 2.87 和 2.82 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PPARγ/GR modulator 1 相关抗体:
体内研究
(In Vivo)

PPARγ/GR modulator 1 (化合物 11) (25-50 mg/kg; 口服给药 5 天) 降低 STZ 诱导的糖尿病小鼠的血清葡萄糖水平，血清乳酸水平和血清脂联素水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-week-old male C57BL/6J mice were injected with180 mg/kg of STZ[1]
Dosage: 25, 50 mg/kg
Administration: Orally administration for 5 days
Result: Significant reduced serum glucose levels, serum lactate levels, and serum adiponectin levels.
分子量

275.23

Formula

C14H10FNO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPARγ/GR modulator 1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARγ/GR modulator 1PPARGlucocorticoid ReceptorPeroxisome proliferator-activated receptorsmetabolic diseasesdiabetesadiponectinleptinInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151963
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