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  4. Prostaglandin E3

Prostaglandin E3 是一种源自二十碳五烯酸的类二十烷酸。Prostaglandin E3 抑制向 M1 巨噬细胞的极化，但促进 M2a 巨噬细胞的极化。Prostaglandin E3 具有抗炎和抗肿瘤活性。

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Prostaglandin E3 Chemical Structure

Prostaglandin E3 Chemical Structure

CAS No. : 802-31-3

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Other Forms of Prostaglandin E3:

Prostaglandin E3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity[1].

体外研究
(In Vitro)

Prostaglandin E3 (1-10000 nM) 在极化巨噬细胞中抑制 M1 并诱导 M2a 标记物表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Prostaglandin E3 相关抗体:
体内研究
(In Vivo)

Prostaglandin E3 (1 µmol/L; i.p.) 在 LPS (HY-D1056) (5 mg/kg) 诱导急性炎症模型中调节巨噬细胞极化以发挥抗炎功能[1]。
Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) 通过调节巨噬细胞极化表现出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5 weeks, Nude mice (BABL/c) (PC3 xenograft model)[1]
Dosage: 1 µmol/L for 50 µL
Administration: Injected next to the tumour, every 3 days for 4 weeks
Result: Decreased the weights of transplanted tumours, inhibits the expression of CD68 and CD206.
Animal Model: 6-8-week-old C57BL6/J mice[1]
Dosage: LPS+ PGE3 (5 mg/kg + 1 µmol/L)
Administration: I.p.; once
Result: Significantly reduced MPMs with an M1-like phenotype and increased M2-like MPMs, inhibited inflammatory cytokine secretion in both the serum and MPM cell lysates.
分子量

350.45

Formula

C20H30O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Prostaglandin E3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prostaglandin E3802-31-3Prostaglandin E 3Prostaglandin E-3Othersmacrophageanti-inflammatoryanti-tumorM2aInhibitorinhibitorinhibit

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