2. Anti-infection Membrane Transporter/Ion Channel Cell Cycle/DNA Damage Apoptosis
  3. Parasite Sodium Channel DNA Stain Apoptosis
  4. Quinacrine

Quinacrine  (Synonyms: Acriquine)

目录号: HY-13735
产品使用指南

摩尔计算器

Quinacrine (Acriquine) 是一种抗疟疾和抗癌剂。Quinacrine 还抑制人醛氧化酶 (aldehyde oxidase) (IC50: 3.3 μM)。Quinacrine 对核酸具有亲和力，并对固定细胞中的 DNA 和 RNA 染色 (Ex/Em: 436/525 nm)。

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Quinacrine Chemical Structure

Quinacrine Chemical Structure

CAS No. : 83-89-6

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Quinacrine 的其他形式现货产品:

Customer Review

Other Forms of Quinacrine:

Quinacrine 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm)[1][2][3][4][7].

体外研究
(In Vitro)

Quinacrine 抑制人和兔醛氧化酶，IC50 分别为 3.3 μM 和 10 μM[2]。
Quinacrine 阻断电压依赖性钠通道 (IC50: 3.3 μM)[3]。
Quinacrine (100 μM) 也是一种 PLA2 抑制剂[4]。
Quinacrine (0-20 μM, 24 h) 抑制 SGC-7901 细胞的生长，并诱导细胞凋亡[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinacrine 相关抗体:

Cell Viability Assay[7]

Cell Line: SGC-7901 cell
Concentration: 0, 5, 10, 15, 20 μM
Incubation Time: 24 h
Result: Inhibited cell growth with an IC50 value of 16.18 μM.
体内研究
(In Vivo)

Quinacrine (3-30 mg/kg，i.p.，每日一次，连续三天) 对甘油诱导的大鼠急性肾损伤具有保护作用[5]。
Quinacrine (2.5-10 mg/kg，i.p.，每天一次，连续八周) 对环孢菌素引起的大鼠肾毒性具有保护作用[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute kidney injury rat model[5]
Dosage: 3-30 mg/kg
Administration: i.p.
Result: Attenuated glycerol induced structural and functional changes in kidney.
Clinical Trial
分子量

399.96

Formula

C23H30ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Quinacrine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinacrine83-89-6AcriquineParasiteSodium ChannelDNA StainApoptosisNa channelsNa+ channelsAntimalarialinfectionDNA stainRNA stainAKIcancerInhibitorinhibitorinhibit

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