Ranatensin 

Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212), Bradykinin (HY-P0206), or Norepinephrine (HY-13715)^[1][2].

Ranatensin (0.3 nM; 30 min) 能够刺激多种胰促分泌物诱导淀粉酶释放^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ranatesin (10-50 μg/mL, 0.1-1 mL; 静脉注射; 单剂量) 会增加狗和兔子的血压，表明其具有直接的外周血管收缩作用 ^[2]。
Ranatesin (10-50 μg/mL, 0.1-1 mL; 静脉注射; 单剂量) 也能降低猴子的血压，与 Eledoisin (HY-P0006) 一样有效。它对血管平滑肌有直接的外周作用 ^[2]。
Ranatesin (10-50 μg/mL, 0.005-0.1 mL; 静脉注射; 单剂量) 根据大鼠血压的基础水平具有可变的作用，在高水平时显示出降压效果，在低水平时升高血压，产生这一变化的可能原因是外周交感神经末梢释放去甲肾上腺素 ^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1281.48

C₆₁H₈₄N₁₆O₁₃S

29451-71-6

Glp-VPQWAVGHFM-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jensen RT, et al. A synthetic peptide that is a bombesin receptor antagonist. Nature. 1984 May 3-9;309(5963):61-3.  [Content Brief]

  [2]. Geller RG, et al. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16.  [Content Brief]