ABCC4 蛋白, Human (HEK293, GFP, Strep, His)

ABCC4 Protein, an ATP-binding cassette (ABC) family member, actively transports endogenous compounds (cAMP, cGMP, bile acids) and xenobiotics from cells. Its versatility extends to glutathione conjugates (LTC4, LTB4) and drug metabolites, mediating cotransport of bile acids with reduced glutathione. ABCC4's function includes resistance to anticancer agents like methotrexate, highlighting its role in cellular communication and drug transport. ABCC4 Protein, Human (HEK293, GFP, Strep, His) is the recombinant human-derived ABCC4 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag. The total length of ABCC4 Protein, Human (HEK293, GFP, Strep, His) is 1325 a.a., .

ABCC4 蛋白是 ATP 结合盒 (ABC) 家族的成员，作为 ATP 依赖性转运蛋白，负责主动从细胞中挤出生理化合物和异生物质。它在运输对细胞通讯和信号转导至关重要的内源分子方面表现出多功能性，包括环核苷酸，如环 AMP (cAMP) 和环 GMP (cGMP)、胆汁酸、类固醇缀合物、尿酸盐和前列腺素。ABCC4 还在谷胱甘肽缀合物（例如白三烯 C4 (LTC4) 和白三烯 B4 (LTB4)）的 ATP 依赖性流出中发挥作用，谷胱甘肽的存在对于 LTB4 的运输至关重要，但对 LTC4 则不然。此外，它介导胆汁酸与还原型谷胱甘肽的共转运。ABCC4的功能范围延伸到多种药物及其代谢物的运输，包括抗癌、抗病毒和抗生素分子，从而赋予对某些抗癌药物（包括甲氨蝶呤）的耐药性。

Human

HEK293

C-10*His;C-GFP;C-Strep

O15439 (M1-L1325)

10257

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.