2. 重组蛋白
  3. Cytokines and Growth Factors Receptor Proteins
  4. Chemokine & Receptors G-Protein-Coupled Receptors (GPCRs)
  5. CC Chemokine Receptor Chemokine Receptor
  6. CCR10
  7. ACKR2 蛋白, Human (Cell-Free, His)

ACKR2 蛋白, Human (Cell-Free, His)

目录号: HY-P700378
产品使用指南

ACKR2 蛋白是一种非典型趋化因子受体，通过高亲和力结合控制趋化因子水平和定位。ACKR2（也称为拦截器或诱饵受体）独立运作，与多种趋化因子相互作用，触发 β-arrestin 1 依赖性信号通路。该通路促进 ACKR2 重新定位，提高趋化因子摄取和降解的效率。ACKR2 清除各种组织中的趋化因子，在解决炎症、调节适应性免疫反应以及影响白细胞与淋巴内皮细胞的相互作用方面发挥着关键作用。ACKR2 在炎症消退过程中对巨噬细胞的免疫沉默有显着贡献。ACKR2 蛋白, Human (Cell-Free, His) 是重组的 ACKR2 蛋白，由 E. coli Cell-free 表达，带有 N-10*His 标签。ACKR2 蛋白, Human (Cell-Free, His) 全长 384 个氨基酸，分子量为 46.9 kDa。

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描述

ACKR2 Protein, an atypical chemokine receptor, controls chemokine levels and localization with high-affinity binding. Operating independently, ACKR2, also known as an interceptor or decoy receptor, interacts with diverse chemokines, triggering a beta-arrestin 1-dependent signaling pathway. This pathway facilitates ACKR2 relocation, enhancing efficiency in chemokine uptake and degradation. Scavenging chemokines in various tissues, ACKR2 plays a pivotal role in resolving inflammation, regulating adaptive immune responses, and influencing leukocyte interactions with lymphatic endothelial cells. ACKR2 contributes significantly to immune silencing of macrophages during inflammation resolution. ACKR2 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of ACKR2 Protein, Human (Cell-Free, His) is 384 a.a., with molecular weight of 46.9 kDa.
研究背景

ACKR2 是一种非典型趋化因子受体，通过高亲和力趋化因子结合协调对趋化因子水平和定位的精确控制，独立于经典配体驱动的信号转导级联运行。ACKR2 也称为拦截器、内化受体、趋化因子清除受体或趋化因子诱饵受体，可作为多种趋化因子的受体，包括 CCL2、CCL3、CCL3L1、CCL4、CCL5、CCL7、CCL8、CCL11、CCL13 、CCL17、CCL22、CCL23、CCL24、SCYA2/MCP-1、SCY3/MIP-1-α、SCYA5/RANTES 和 SCYA7/MCP-3。在活性配体刺激下，它会触发 β-arrestin 1 (ARRB1) 依赖性、G 蛋白独立信号通路，通过 RAC1-PAK1-LIMK1 信号级联导致肌动蛋白结合蛋白肌动蛋白丝切蛋白 (CFL1) 磷酸化。该通路的激活促进 ACKR2 从内体区室重新定位到细胞膜，从而提高其趋化因子摄取和降解的效率。通过清除组织、淋巴管表面和胎盘中的趋化因子，ACKR2 在解决炎症反应和调节适应性免疫反应中发挥着关键作用。此外，它是炎症白细胞与淋巴内皮细胞 (LEC) 相互作用的关键调节因子，对于 LEC 识别未成熟/成熟树突状细胞至关重要。ACKR2 还对炎症消退过程中巨噬细胞的免疫沉默有显着贡献。
种属

Human
表达系统

E. coli Cell-free
标签

N-10*His
蛋白编号

O00590 (M1-A384)
基因 ID
蛋白结构
N-term
10*His
ACKR2 (M1-A384)
Accession # O00590
C-term
同用名
ACKR2; atypical chemokine receptor 2; CCBP2; chemokine binding protein 2; CMKBR9; chemokine-binding protein 2; CCR9; CCR10; D6; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61; hD6; MGC126678; MGC138250;
氨基酸序列

MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDMVFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQSENYPNKEDVGNKSA

分子量

46.9 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ACKR2 Protein, Human (Cell-Free, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
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